Faculty Research: William M. Atkins

Degrees:
1980 B.S. Chemistry. The College of William & Mary. 1983 M.A. Pharmacology. Harvard University 1988 Ph.D. Biochemistry. University of Illinois at Urbana-Champaign.

Areas of Research:

Bio-Inspired Materials	Hybrid Materials
Hydrogels	Self-Assembled Systems

Selected Publications:
representative papers:

Dabrowski, M.D., Schragg, M. D., Wienkers, L. & Atkins, W.M. (2002) "Pyrene-pyrene Complexes at the Active Site of Cytochrome P450 3A4: Evidence for a Multiple Substrate Binding Site." J. Am. Chem. Soc. 124: 11866-11867.



Atkins, W.M., Lu, W.D. & Cook, D.L. (2002) "Is There a Toxicological Advantage for Non-hyperbolic Kinetics in Cytochrome P450 Catalysis? Functional Allostery From Distributive Catalysis." J. Biol. Chem. 277: 33252-33266.



Lyon, R.P. & Atkins, W.M. (2002) Structural and Kinetic Characterization of Cys-112-modified Glutathione S-Transferase A1-1: Reassessment of the Ligandin Binding Site." Biochemistry 41: 10920-10927.



Lyon, R.P. & Atkins, W.M. (2001) "Self-assembly and Gelation of Oxidized Glutathione in Organic Solvents." J. Am. Chem. Soc. 123: 4408-4413.



Nieslanik, B.S., Ibarra, C. & Atkins, W.M. (2001) The C-terminus of Glutathione S-transferase A1-1 is Required for Entropically-driven Ligand Binding. Biochemistry 40: 3536-3543.



Schurke, P., Freeman, J., Dabrowski, M.J. & Atkins, W.M. (1999) "Metal-dependent Self-assembly of Protein Tubes From E. coli Glutamine Synthetase: Cu2+ EPR Studies of the Ligation and Stoichiometry of Intermolecular Metal Binding Sites." J. Biol. Chem. 274, 27963 - 27968.



Dabrowski, M. D., Chen, J.P., Shi, H., Chin, W.C. & Atkins, W. M (1998). "Strategies for Protein-based Nanofabrication: Ni2+-NTA as a Chemical Mask to Control Biologically-imposed Symmetry," Chemistry & Biology 5, 689- 697."



Dabrowski, M.J., Chen, J.P. & Atkins, W.M. (1997) "Synthesis and Characterization of Supramolecular Protein Aggregates: Self-assembled, Molecularly-ordered, Protein Tubes from Electrostatic Complementation of Glutamine Synthetase Dodecamers." Protein Engineer. 10, 1289 - 1294.



Dabrowski, M. D. & Atkins, W. M. (1995). "Engineering Macromolecular Self-Assembly: Molecular Tubes vs. Protein Sheets via Single Amino Acid Substitutions in E. coli Glutamine Synthetase." Adv. Mater. 7, 1015 - 1017.



Schurke, P. J., Dabrowski, M. J., Yanchunas, J., Cader, B. M., & Atkins, W. M. (1994) "Supramolecular Self-assembly of E. coli Glutamine Synthetase: A Novel Intermolecular Metal Binding site Mediates Dodecamer Stacking." Biochemistry 33, 14957 - 14964.

Research Keywords:
protein-based materials, drug design

Experticed Keywords:
protein engineering, molecular self-assembly, protein devices