Faculty Research: Valerie Daggett

Daggett, Valerie
Professor
Bioengineering
Lab Website: http://depts.washington.edu/~daglab
Office Location: N310B, Foege North
Office Phone: 685-7420
Office Fax: 685-3252
Lab Location: Hall Building, 616 NE Northlake Place, 300H
Lab Phone: 616-2780
Lab Fax: 685-3300

Degrees:
1983, BA, Chemistry, Reed College 1990, PhD, Pharmaceutical Chemistry, UCSF, Postdoc Stanford University

Awards and Professional Activities:
ONR Young Investigator Award

National Academy of Sciences’ Frontiers of Science Symposium

Senior Editor of Protein Engineering Design and Selection (PEDS)

Participant/lecturer for Royal Society Discussion Meeting on New Science from High Performance Computing, I represented Biomolecular Modeling (10/2001)

Editorial Boards: Structure with Folding and Design (1995-present), Protein Science (1996-1999, 2000-2003), Principal Editor for TheScientificWorld (2000-2001), Structural Biology section of Biomed Central, electronic publications (2001-2003), Biochemistry (2003-present).

Research in NanoTechnology:
Single-molecule atomic characterization of structure and dynamics Drug Design Biosensor and biomaterial design

Areas of Research:
Nano-MEMS
Bio-Inspired Materials
Self-Assembled Systems
Biological Nanosystems

Selected Publications:
2004

98. DeMarco, M.L. and V. Daggett, From Conversion to Aggregation: Protofibril Formation of the Prion Protein, Proc. Natl. Acad. Sci. USA, 101, 2293-2298, 2004.

99. Bennion, B.J. and V. Daggett, Counteraction of urea-induced protein denaturation by TMAO: A chemical chaperone at atomic resolution, Proc. Natl. Acad. Sci. USA, 101, 6433-6438, 2004.

100. Sato, S., Religa, T., Daggett, V. and A.R. Fersht, Testing protein folding simulations by experiment, Proc. Natl. Acad. Sci. USA, 101, 6952-6956, 2004.

101. Jemth, P., Gianni, S., Day, R., Li, B., Johnson, C.M., Daggett, V. and A.R. Fersht, Demonstration of a low energy on-pathway intermediate in a fast folding protein, Proc. Natl. Acad. Sci. USA, 101, 6450-6455, 2004.

102. Armen, R.S., DeMarco, M.L., Alonso, D.O.V. and V. Daggett, Pauling and Corey’s alpha-pleated sheet structure may define the prefibrillar amyloidogenic intermediate in amyloid disease Proc. Natl. Acad. Sci. USA, 101, 11622-11627, 2004.

103. DeMarco, M.L., Alonso, D.O.V. and V. Daggett, Diffusing and colliding: The atomic level folding/unfolding pathway of a small helical protein, J. Mol. Biol., 341, 1109-1124, 2004.

104. Beck, D.A.C. and V. Daggett, Methods for Molecular Dynamics Simulations of Protein Folding / Unfolding in Solution, Methods, 34, 112-120, 2004.

105. Armen, R.S., Alonso, D.O.V. and V. Daggett, Anatomy of an amyloidogenic intermediate: Conversion of beta-sheet to alpha-pleated sheet structure in transthyretin at acidic pH, Structure, in press, 2004.

106. Bennion, B.J., DeMarco, M. and V. Daggett, Preventing misfolding of the prion protein by Trimethylamine N-oxide, Biochemistry, accepted, 2004.

107. Beck, D.A.C., Armen, R.S. and V. Daggett, Cutoff size need not strongly influence molecular dynamics results on solvated polypeptides. Biochemistry, accepted, 2004.

Press Articles and News:
Recent: Nature. New Role for Pauling’s Ribbons by Christopher Surridge, 430, 739, 2004. Science. A Neatly Pleated Alpha Sheet, by Orla Smith, 2004 in press.

Positions Available:
Yes

Research Keywords:
molecular modeling, computational chemistry, protein folding, misfolding diseases, molecular dynamics, biopolymers, smart materials, elastin-like peptides, biosensors

Experticed Keywords:
molecular modeling, computational chemistry, protein folding, misfolding diseases, molecular dynamics